Jun 11, In this article, we discuss some of the current research that has come out in regards to CBD oil for Alzheimer's Disease, in the hopes of. Alzheimer's and the topic of CBD health benefits continues to symptoms can often be reduced by using CBD oil. Sep 24, Before we get looking at CBD oil for Alzheimer's disease though, is CBD oil exactly, and should you use it as a practical treatment option?.
Oil for it a Is CBD Practical Treatment? Alzheimer’s Disease:
One of the most noticeable effects that many people report after taking CBD oil is a pleasant and powerful reduction in anxiety and a noticeable lift in mood. One study of CBD extract on anxiety used functional magnetic resonance imaging fMRI , which is a sophisticated brain activity mapping tool, to study what happened to the brain when participants took mg of CBD extract while being exposed to stress- and anxiety-inducing stimuli.
What they found was that CBD calmed the amygdala and cingulate cortex, two important areas of the brain well-known to control fear, stress levels and anxiety, among other things. In another study, Brazilian researchers investigated the effect of CBD extract on human cortisol levels in eleven volunteers. They found that CBD decreased cortisol levels significantly more than the placebo and that most subjects also reported a sedative effect from the treatment.
Moreover, Cannabidiol extract was shown to reduce anxiety in [human] patients with social anxiety disorder. Multiple animal studies have shown that CBD has a remarkable ability to suppress certain cellular processes that lead to inflammation and, as a result, pain. These studies found that Sativex was able to reduce pain associated with central and peripheral neuropathy, rheumatoid arthritis, and cancer to varying degrees in most of the study participants.
Although the jury is still out as to how effective CBD oils and extracts are for inflammation , many who have been struggling with inflammation-related diseases like arthritis have reported that CBD oils, extracts and creams containing CBD have helped reduce some of their symptoms. Although not as common, studies on animals and a few, small human studies in the case of epilepsy also found that Cannabidiol shows promise as a potential treatment for seizures, diabetes and nausea, among other things, although more research is needed.
With that being said, as mentioned previously, many feel a marked sedation and even feelings of bliss or profound relaxation after ingesting high-quality CBD oils and extracts. Others report that the dramatic, positive shift in mindset that CBD oil can produce is useful in seeing life from a different perspective that often times lends itself to new insights, ideas, and closure about things that previously bothered them.
Seek products that are completely organic or at least contain organic CBD as these are guaranteed to be free of harmful chemicals and solvents that are sometimes used in the extraction process of less-reputable companies just out to make a buck. All widely available, legal CBD products are extracted from the hemp plant, and particularly hemp oil, whereas products that are legal in some places but illegal in others depending on local jurisdiction are often extracted from cannabis marijuana plants and contain significant and varying levels of THC.
There is some evidence that small amounts of THC increase the effectiveness of CBD, however, it is not required to reap the benefits of taking Cannabidiol. Research has shown pure CBD extracts from hemp and hemp oil, as long as the CBD is of high quality, are similarly effective and beneficial. However, in more serious, chronic illnesses there may be additional benefits from having THC in the mixture, such as more pronounced pain reduction and medicinal effects, according to the various human studies conducted on the compound.
It is also important to consider potency when choosing CBD products as well. Generally speaking, the effects of CBD are dose dependent to some degree, meaning that the more that is ingested, the more pronounced its effects are. There are a wide range of Cannabidiol product potencies available, but a good starting point for most people is for one dose of the product to be in the 2mg to 7mg range, with the latter being on the stronger side. If you know you tend to be sensitive to natural products and medicines, start at a lower dose.
For most CBD hemp oil products, you can take a partial or double dose to adjust the potency. When in doubt consult a qualified naturopath or doctor. As always, when starting new herbs or natural medicines like Cannabidiol, be sure to start slow to understand how your body reacts and work up to higher dosages over time.
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The endocannabinoid system, which may play a role in epileptogenesis, includes 2 G-protein coupled receptors cannabinoid type 1 [CB1] and cannabinoid type 2 [CB2] and 2 endogenously synthesized, lipid-signaling endocannabinoids anandamide [ N -arachidonyl ethanolamide] and 2-arachidonoyl glycerol [2-AG] that bind to CB1 and CB2.
A presynaptic receptor, CB1 is highly expressed in the hippocampus, amygdala, cingulate, cerebral cortex, basal ganglia, midbrain, and medulla.
Therapeutic effects of CB1 binding are via modulation of neurotransmitter release, including dopamine, GABA, glutamine, serotonin, norepinephrine, and acetylcholine. Concentrated in peripheral immune tissues i. In the context of seizures and epilepsy, although it seems CB1 would be a likely target, that does not appear to be the case. Cannabis contains more than unique compounds called phytocannabinoids, which are quite similar to lipophilic endocannabinoids—differentiated only by the origin of synthesis ie, plants.
There are mixed reports of seizure treatment success and seizure exacerbation. Some believe this is a benefit as it may have less potential for abuse. CBD is highly lipophilic and becomes distributed in the brain rapidly. Much remains to be ascertained regarding cannabis and its precise mechanism s of action in epilepsy. Overall, most side effects were well tolerated.
This is significant both clinically and statistically as positive perception may positively affect patient outcomes.
Both groups of patients treated had larger reductions in drop seizures Patients experienced statistically significant decreases in convulsive seizures per month after 12 weeks; this was sustained through week 48 of the study. The largest effects were seen for tonic-clonic seizures Side effects were similar to previous reports ie, drowsiness, ataxia, diarrhea. A large analysis of expanded access to pharmaceutical-grade CBD included patients and 25 institutions. Data are lacking for nonconvulsive seizures, which are more difficult to quantify; the studies discussed in this article were not designed to assess this endpoint.
The majority of studies described in this article involve a single, standardized formulation of CBD created with cannabis grown and CBD extracted under extremely strict conditions, as would be required for any drug approved for human consumption.
There are a number of artisanal CBD products available from dispensaries and online retailers, many touting their efficacy for epilepsy and other conditions. Unlike the recently FDA-approved formulation, artisanal CBD products are considered supplements and do not have the same regulatory oversight.
As a result, these products cannot be labeled to state claims of health benefit. The consumer must be aware these products may vary widely in contents and purity. A study examined the accuracy of CBD labeling on artisanal products and found that of 84 different CBD extracts reviewed. This is not to say that artisanal cannabis products may not be efficacious for epilepsy. Practitioners simply need to be aware of the differences.
Although there is good evidence for safety and efficacy of CBD, many artisanal products may contain high amounts of other cannabinoids for which research is lacking. Consequently, patient response and potential adverse effects are unknown and should be taken into consideration when discussing the risks and benefits of this type of therapy.
The recommended starting dose of pharmaceutical-grade CBD is 2. Milder side effects included somnolence, fatigue, diarrhea, and reduced appetite. Hepatotoxicity has emerged as an adverse effect of CBD treatment of particular concern. Many antiepileptic drugs AEDs carry some risk of hepatotoxicity, but with a clear monitoring plan, this concern could be reduced.
Elevation of LFTs appears to be most common in the first 2 months of treatment but has also been observed in later stages of treatment. Liver monitoring is recommended at months 1, 3, and 6 after initiating treatment with pharmaceutical-grade CBD or monthly after dose changes or addition of another AED that interacts with CBD. The hepatotoxicity risk of pharmaceutical-grade CBD appears to be more common if there is polypharmacy with valproic acid products or clobazam, although LFT elevation has also been shown to occur without these concomitant drugs.
Varying reports of alterations in serum concentration of rufinamide, topiramate, zonisamide, and eslicarbazepine have also been noted. Close monitoring may be encouraged or even required. Alone, CBD has no schedule designation, but as a component of marijuana, it has been listed as a schedule I drug—defined by the Drug Enforcement Administration DEA as a substance having high potential for abuse with no medical efficacy.
This will occur imminently in the US prior to expected release of pharmaceutical-grade CBD in late How this will affect the legality of artisanal CBD products is less clear, as many may contain unacceptable amounts of THC and other cannabinoids which are likely to remain schedule I until there is more evidence for safety and efficacy. Cannabis law varies widely across the US from state to state, further complicating procurement for patients choosing not to use the FDA-approved product.
CBD and marijuana laws vary internationally as well. Several countries allow utilization of cannabis for medical purposes, but the cultivation and possession of marijuana for recreational use remains largely illegal. In the United Kingdom, once pharmaceutical-grade CBD is approved, lawmakers plan to re-examine current laws to allow for legal utilization of this CBD product.
The cost of treatment is another factor that warrants discussion. Currently, CBD oils procured from dispensaries are not covered by health insurance as they lack accepted evidence of efficacy. Cannabis and CBD have a long history of use for medical purposes throughout human history. Until recently, standardized studies with large datasets have been lacking.
Now, with the change in social climate and attitude towards the potential of cannabis and CBD, data are amassing to provide much-needed insight into the practical application of CBD in patients with seizures and epilepsy. More studies are needed to determine the exact mechanism of therapeutic efficacy ie direct antiepileptic target vs. Practitioners still must be cognizant of individual patient factors because CBD is not a benign entity.
Vigilance for concomitant hepatotoxic antiepileptics, potential interactions, and side-effects must be maintained and cost and variability between different formulations considered. New options are on the horizon and expanding potential medical treatment with CBD. Governmental acceptance of a CBD-based product is helping to open doors for many families and patients with previously limited options.
The CBD safety and efficacy profiles combined with the great need for better treatment options in refractory epilepsy make this a promising therapy for patients and practitioners alike.
We are likely experiencing the first among many therapies to be derived from the cannabis plant in the coming years. Friedman D, Sirven JI. Historical perspective on the medical use of cannabis for epilepsy:
Cannabis, Cannabidiol, and Epilepsy
Jan 25, The researchers concluded that “adding medical cannabis oil to Alzheimer's patients' pharmacotherapy is a safe and promising treatment. Sep 2, (Cannabis Pharmacy: The Practical Guide to Medical Marijuana, Michael Backes, ) Behavioral and psychological symptoms of dementia. Oct 10, As a form of dementia, Alzheimer's disease wreaks havoc with a However, new Alzheimer's treatments, such as cannabis oil, may slow the.