Can CBD Oil Treat Rheumatoid Arthritis Symptoms? Medically reviewed by If you don't notice any side effects, you can try slowly increasing your dosage. CBD oil dosage depends largely on the disease. Everyones dosage needs are different, it is best to start with a small CBD dose and increase slowly Broken Bones · Mad Cow Disease · Depression · Bacterial Infections · Diabetes · Rheumatoid Arthritis · Nausea .. I have severe arthritis of both knees and right hip. I have. Learn more about CBD oil and what the science says about how its effectiveness for For example, a analysis of human trials for RA, OA and fibromyalgia found that CBD If that doesn't help, try a CBD product with a low dose of THC.
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Cannabis sativa and its constituents have proven to be both safe and effective when it comes to pain management. With the legality of marijuana spreading across the United States and other countries, many people are now being given the opportunity to switch from dangerous, addictive medications to a natural, safer alternative.
Whether you are suffering from chronic nerve or body pain, or you are experiencing short-term pain from muscle strain, headaches, toothaches, or simply sore muscles, cannabis offers a safer and possibly more effective option than what is typically used for pain today.
Throughout this time, the cannabis plant has been exalted as miraculous and cursed as a danger to the fabric of society. Yet, throughout this varied past, one thing has remained the same: Cannabis has been used as a plant medicine for the treatment of an impressively wide array of diseases.
The earliest evidence of its medicinal use dates back to BC when Chinese Emperor Shen Nung documented the analgesic pain-relieving properties. Shen Nung is considered by many to be the father of Chinese medicine, which has helped to heal people through the use of natural remedies for thousands of years. We have now entered a time where the benefits of this plant are beginning to come back to the forefront of the discussion.
Indeed, countless individuals across the world have access to legal marijuana for chronic pain conditions. Should patients turn to singular compounds found in the plant, or turn to the plant itself? If using the whole plant, what marijuana strains are the best for providing relief from pain? When you compare Western medicine to traditional medicine the world over, one of the most striking differences is the need in the West to pinpoint one specific molecule that is responsible for treating a disease or symptom.
This viewpoint stands contrary to the idea of holistic medicine, where you take something in its entirety for medicinal purposes. The Cannabis sativa plant is one of the greatest present-day examples of this tug-of-war between Western medicine and traditional medicine.
It has been found to have a variety of health-related benefits for the user. CBD is the second most well-known cannabinoid found in cannabis, and like most of the other phytocannabinoids, it is non-psychotropic. These are the two most abundant and well-studied cannabinoids in marijuana, and both have been found in numerous published studies to have pain-relieving properties in humans.
While they may be the most abundant, THC and CBD are certainly not the only compounds found in cannabis that are known to exert positive effects on human health. In every cannabis plant, there is a unique mixture of hundreds of plant compounds, comprised of phytocannabinoids, terpenes, and flavonoids.
Research suggests that these compounds too have an influence on our neurochemistry, and together they may work synergistically, producing better improvements in pain relief than anyone would produce on its own. This research supports the idea that it is best to use the whole cannabis plant, with CBD, THC, and the natural medley of additional compounds.
This harmony between the various plant chemicals found in marijuana is colloquially referred to as the entourage effect. The most well-studied compounds found in the marijuana plant that support the idea of the entourage effect are THC and CBD, which have been found to work differently together than when separate. Using these two compounds in concert has been shown to help mitigate side effects and enhance efficacy, with CBD plus THC showing more benefit for some conditions than THC alone.
It has also been found to extend the half-life of THC, which may help to extend the pain-relieving benefits. This has allowed the use of higher doses of THC in clinical trials for the treatment of pain caused by multiple sclerosis, peripheral neuropathic pain, intractable cancer pain, and rheumatoid arthritis.
When used in concert, a greater efficacy in treating these types of pain have been observed. Every strain of bud that you can purchase at a dispensary will be labeled with its THC and CBD content, which can be helpful when choosing which strain to choose for pain relief. CBD has been found to exhibit enhancements in treating pain both when used on its own and when used in combination with THC.
When used alone, CBD is largely best for inflammatory pain, such as that caused by arthritis or injuries. In one animal study on arthritis pain, it was found that the topical application of CBD led to a reduction in inflammation and pain.
Another animal study found that CBD helps to reduce neuropathic pain through the suppression of chronic inflammation. CBD does not directly bind to the receptors found in the endocannabinoid system but rather works to modulate the effects of the endocannabinoids the cannabinoids found naturally in our bodies as well as working as a CB1 receptor antagonist.
The main mechanism by which CBD is thought to help mediate pain is by reducing inflammation , largely by blocking inflammatory mediators. It is also believed to potentiate glycine receptors, which help to regulate pain at the spinal level.
This suppresses both neuropathic and inflammatory pain. THC is used clinically for the treatment of pain and studies find it helps relieve central and neuropathic pain.
It is also used to help reduce pain in cancer, AIDS, and fibromyalgia patients, for which resistance to other pain treatments have been found. The mode of action for THC is as a partial CB1 receptor agonist, which means that it will bind to these receptors but not fully which leads to the variability in effects documented when THC is present with other CB1 agonists, antagonists or both.
It has been found to impact the serotonergic, dopaminergic, and glutamatergic systems — an action which may contribute to its pain-relieving benefits.
Additionally, THC has been found to act as an anti-inflammatory agent. While human studies have found benefits from the use of THC, CBD, and whole-plant marijuana in relieving pain, much of the evidence for this use comes from user reports and surveys. When searching for the best cannabis strains for pain relief, you will first want to consider how much THC and CBD is found in the strain. Smoking is one of the things known to be one of the triggers of inflammatory arthritis.
Metabolic arthritis occurs when there is too much uric acid in the body. When excess uric acid builds up, it can cause crystals to form in the joints. This causes extreme pain and can lead to gout. We all need uric acid in our bodies, but some people produce more than they need. There have been many reports of the benefits of using CBD oil for arthritis. Some people have even reported that it has changed their lives.
The therapeutic benefits of CBD oil are also backed up by medical research studies. CBD oil is a natural substance derived from the hemp plant. It is one of a group of compounds known as cannabinoids. When cannabinoids interact with the endocannabinoid system, it helps to regulate pain and inflammation. CBD oil also has other effects. It helps people sleep and it has an anti-anxiety effect. Overall, CBD oil for arthritis has the potential to reduce pain and inflammation.
It can also make coping with the disease much easier. There have been many studies into the analgesic and anti-inflammatory properties of CBD oil. The researchers concluded that CBD has the potential for the relief of arthritis-related pain and inflammation. They also noted that CBD had no side effects. CBD oil is a natural, non-toxic compound that is found in the hemp plant. There are no real known serious side effects of CBD. There is often confusion between CBD products and cannabis products.
They think that it may make them high and it may be illegal but this is far from the truth. The substance that causes a high is called tetrahydrocannabinol THC. This compound is found in very high concentrations in marijuana plants but low concentrations in hemp plants.
For this reason, hemp derived CDB products are legal in all 50 states. Marijuana-derived CDB products, however, are not. Some states, though, do allow the use of marijuana-derived CDB products for medicinal use. There are several types of CBD oil for arthritis products available.
They will all reduce pain and inflammation. These types of products are best used for flare-ups of pain. For long-term relief of arthritic pain, ingestible CBD products are usually more effective. These types of products take longer to make their way through the digestive system, but the effects will last longer. For more focussed relief, you can also use CBD oil salves and lotions. These can be massaged directly into painful joints. These triggers cause a cascade of inflammatory effects 1.
Synovial cells increase in size and quantity, eventually signaling an increase in mononuclear cells lymphocytes and monocytes , and causing the proliferation of T-cells. Once activated, these T-cells secrete cytokines and chemokines which increase inflammation to fight the antigen. Cytokines activate another lymphocyte B-cells increasing the production of antibodies and increasing inflammation. Cytokines also increase mast cells which release histamines to attack antigens.
In rheumatoid arthritis, other types of cells — fibroblasts, osteoclasts, and macrophages — also increase, further worsening the inflammatory process. This causes thickening, swelling, inflammation of the synovium, and a release of destructive enzymes.
When inflammation occurs, and cytokine levels rise, blood vessels in the synovial membrane open causing more blood flow and faster synovial cell growth. This cell growth leads to increased thickness of the synovium, unevenness, and roughness of the surface. The synovium expands into other areas to accommodate for its increased thickness.
Pannus cells migrate to this area covering the surfaces while secreting excess fluid and enzymes, degrading cartilage and bone. The high number of osteoclasts in the pannus layer secrete proteins and produce an acid which destroys bones leading to increased pain, decreased joint movement, and development deformities.
Long-term use of these arthritis medications can cause serious complications 4 like damage to the liver, kidneys, eyes, lungs, heart, GI, and neuropathy. The endocannabinoid system 5 ECS , although found throughout the body, is predominantly located in the central and peripheral nervous systems.
ECS receptors are found in organs, glands, connective tissues, and the immune system. Their primary function is to promote homeostasis in the body. However, receptors also play a role in pain sensation, inflammation, mood, memory and learning processes, appetite, locomotion, and other physiological processes.
The nervous systems, organs, glands, and connective tissues mostly have CB1 receptors; while the immune system and peripheral system predominantly have CB2 receptors.
CB1 receptors play a vital role in pain sensation, mood, appetite, sleep, and memory, and produce the psychoactive effects of cannabis. Whereas, CB2 receptors affect the inflammatory process and suppress the immune system. The ECS responds to endocannabinoids cannabinoids created within the body. However, they are produced only when needed, and their effects are localized and short-lived since they are easily degraded by enzymes. The ECS is known to be essential for homeostasis of the body, and many studies have been conducted to determine if phytocannabinoids cannabinoids from cannabis , working in conjunction with endocannabinoids, can be more effective than conventional treatment options for arthritis.
THC, the most common cannabinoid, controls how pain is perceived by the brain.
cbd dose for rheumatoid arthritis
Thus, cannabis oil, or CBD oil as it is more commonly known, is an oil . However, when talking about proper CBD dosing, it's important to first. Studies suggest that CBD oil could play a role in treating arthritis and other Rheumatoid arthritis (RA): An autoimmune disease in which a. The best news when it comes to using CBD oil for rheumatoid arthritis is that there are multiple forms to choose from along with a varied range of dose usage .