Cannabidiol (CBD) combined with some THC has been shown to be effective for like PTSD, SAD, GAD, OCD, social phobia and anxiety induced insomnia. Notably, PTSD and OCD are no longer classified as anxiety disorders in the .. treatment of GAD, SAD, PD, OCD, and PTSD, and suggests that CBD has the .. Fear relief-toward a new conceptual frame work and what endocannabinoids. Cannabidiol oil, an increasingly popular treatment of anxiety and sleep and improving sleep in a young girl with posttraumatic stress disorder. inflammation , decreasing anxiety and depression, improving sleep, . CBD: how it works. ( CBD) in generalized social anxiety disorder: a preliminary report.
OCD For GAD, Depression, Insomnia Works CBD Anxiety, SAD, And Oil PTSD,
It really comes down to the perfect strain and dose. You can make almost any cannabis work for you with those two things in mind. Holy cow I wish I had seen this a year ago. I found out how horrible the effect of long term benzodiazepine use, 8 years for me also, and I went through 4 months of extreme agony.
I am in process of trying different indicas for non anxiety producing relaxation and pain relief. I found northern lights worked the best for me. Blueberry kush and BlackBerry kush too but they are hard to find. Berry white works great too, i believe it is part black or blue berry and northern lights, which is why it is white. Really helps me not use as many benzos. But, you want indica aka in da couch, not sativa.
But it is better than docs trying to lower the benzos and give you no other option than up other meds that is too much for me. For me marijuana is the best medication for anxiety and other illness. They are several strains better than xanax bars for the use of anxiety.
You can get some from marijuanahousenv. This is awesome and helpful. Thanks to Bailey Rahn for compiling this article. While I thought that was linked to the various US state which lives in tyranny; now I realize it was most likely a garbage product.
As we begin to experience more decriminalization, more sufferers of various anxieties can finally use marijuana products to manage them. It looks like Granddaddy Purple or Cannatonic would be a good match for me.
I have smoked weed for 30 years. I used to just smoke for the enjoyment, but I did have mild anxiety. When I was about 20 I got super high and had the worst experience! The room spun, I vomited, and I was extremely paranoid. Fast forward a few years. I also have IBS, chronic pain from herniated discs in my neck, and back, and a neurological disorder idiopathic intracranial hypertension that causes headaches non stop for years , dizziness, vertigo, nausea, and pain ears, face, eyes, all down spine, arms, shoulders.
Ever since the bad reaction at 20 it only takes me a small amount to get high, and my experiences have been hit or miss. Sometimes it helps me relax, others like right now, which is how I found this article it increases my anxiety a LOT.
Recently it seems to be doing nothing but increasing. I too share your anxiety issues. I stay away from the 1: I am slowly getting more used to the CBD strains and can take more and more all the time, so its a process, you just have to start out small… Hope that helps…. I actually do only smoke small amounts. I did that enough when I was young. I just want a little symptom relief. Stacy, I am the same way with pot minus all of the disorders you have to deal with. I just have severe anxiety and I found when I smoked weed it set me up for a panic attack.
I loved the sensory euphoria it gave me but hated feeling the doom or panic. Then other times I would have the most therapeutic experience, I learned something. It is all about strain and tolerance. I have learned what my dose is and I dose myself strictly also I only smoke a handful of strains.
What helps me is one pull of a joint, or rip of a pipe or two pulls from a vape for an initial dose, wait an hour and then have more as needed. These 3 strains is all you need to have you enjoying cannabis stress free at least in my experience. When normally you would be panicking or pacing with the sudden change in your mental state.
But you have to grow it yourself or have someone grow it for you. So you know what your getting is authentic. Seeds can be purchased online discreetly, just a google away growing a couple of plants is easy and safe good luck! I only smoke small amounts. It probably does have to do with strains. I have no way to grow it myself, or have someone grow for me, but I only buy from dispensaries. Hi, are you smoking anything that works for you.
I have somewhat similar problems: Do you have anything to recommend? Honestly, just going through the list of strains of what relief is associated with each one is a great start. Make a list of what has potential benefit for you and then visit the shops with your list.
The budtenders will try to help you out, so be clear about your effects that you want. As mentioned before, start low and go slow. Since you would have a list already prepared, that list will be good to update with YOUR own responses to each strain as you try them out. When I lived in Oregon, I came across a few strains that I just loved and kept those notes until I left.
What I ended up discovering is that I get marvelous results from marinating my own flower in butter and then baking something with it. I get the full complement of the plant, my back pains are muted, my brain chatter gets muted, and everything is just great….
Many studies have been published that point to the efficacy of cannabis components for conditions you have mentioned. I have no affiliation with any organization; I speak purely as a fellow seeker, and have found relief micro-dosing CBD and THC, using a 1: It may be frustrating sorting through, and I know how alone chronic unresolved problems as you describe can make one feel.
No one deserves to suffer. But now with medical, you can pick what works best. First i started with gummy bears edibles but they knock you out. Ive found northern lights, berry white, blueberry and blackberry are good. High in cbd which is good. Weed is super strong nowadays so you need one or two puffs unless you have a tolerance. Downside, munchies, sleepy unless you get a hybrid oid sativa and indica. I live birther lights but it is always out. Sure would be nice to live in a legal state.
I have to take whatever comes along and now I had to take a hiatus because my dealer wants me to straw buy him a gun. I recommend them to anybody who needs help. She loves that there are no side effects. I have ordered twice from this company, and each time the deliveries were prompt. All two arrived in the next business day. Get to him via his number I use the CBD which helps me, I feel great!
I believe this product. I have a discount coupon from Elixinol and I can share it: Get him out and benefit from his good services via My favorite strains for anxiety gad is purple Kush and crown Royal. Microdosing is definitely the route for me as I am lightweight and too much of any strain really sets it off.
At least for me anyhow, one or two hits and im couch locked bigtime. Does anyone know of a strain that can help with muscle and nerve pain, but still keep me productive? I own my own business, and have tons of clients to attend to on a daily basis. I need a clear head, and no pain. I recommend Kosher Kush and LA confidential, works very well for me, relaxes, sets peaceful state of mind, takes stress away.
Unfortunately LA Confidential is a small yeld strain, very hard to find and expensive. I use to be able to smoke my self stupid on weed or take a few small hits and get my perfect high and love it up until one bad incident; cold sweats, racing heart, fainted twice, shallow breathing. It was a night mixed with alcohol too and very little to eat. Biggest thing was, I think I had went cold turkey off of anti-depressants a few months prior and I know for sure that had something to do with it.
Christ, I recently had a night terror about smoking weed. I got too high in my dream and started panicking then woke up on the verge of a panic attack. I suffer from some severe anxiety and panic attack disorder.
I do take meds for it, but I still wake up almost every morning with a bit of anxiety. The last time I ever took what most casual smokers would consider a couple normal hits of weed my heart started racing shortly there-after and my wife was away for the weekend so I had to pop two lorazepam to straighten me out.
I drove my self to the hospital with a heart rate of about or so and left about 15 minutes after I got there because of course I started feeling a hell of a lot better once I knew I was in a hospital, lol. Being able to think back about all my panic attacks and anxiety episodes has really helped me be able to fight the anxiety and panic attacks to prevent them, but if it gets bad enough the anxiety always seems to win in the end.
I tend to stay away from smoking and drinking, because they both give me anxiety if I have too much of either one. A very informative post with a lots of essential information shared here. The first method to picking a good strain to combat your anxiety is recognizing your sufferance and step two involves in experimenting with new concentrates to select which one is suited you the most.
Aside from choosing the correct strain, dosage, environment, and method all play a role too. I have learned that I can only use indica.
Hybrids and sativa give me the most paranoia and anxiety. With indica I feel relaxed, at ease, comfortable and chill. Thank you for this info. Neuroimaging studies that documented results from anxiety-related tasks, or resting neural activity, were included. THC ratio , were included. Cannabis sativa , a species of the Cannabis genus of flowering plants, is one of the most frequently used illicit recreational substances in Western culture. The 2 major phyto- cannabinoid constituents with central nervous system activity are THC, responsible for the euphoric and mind-altering effects, and CBD, which lacks these psychoactive effects.
Preclinical and clinical studies show CBD possesses a wide range of therapeutic properties, including antipsychotic, analgesic, neuroprotective, anticonvulsant, antiemetic, antioxidant, anti-inflammatory, antiarthritic, and antineoplastic properties see [ 11 , 12 , 16 — 19 ] for reviews. Pharmacology relevant to these actions is detailed below. The primary mechanism by which eCBs regulate synaptic function is retrograde signaling, wherein eCBs produced by depolarization of the postsynaptic neuron activate presynaptic CB 1 Rs, leading to inhibition of neurotransmitter release [ 23 ].
Interactions with the TRPV1 receptor, in particular, appear to be critical in regulating the extent to which eCB release leads to inhibition or facilitation of presynaptic neurotransmitter release [ 25 ]. TRPV1 receptors are also expressed in the brain, including the amygdala, periaqueductal grey, hippocampus, and other areas [ 26 , 27 ].
The eCB system regulates diverse physiological functions, including caloric energy balance and immune function [ 28 ]. The eCB system is also integral to regulation of emotional behavior, being essential to forms of synaptic plasticity that determine learning and response to emotionally salient, particularly highly aversive events [ 29 , 30 ].
Activation of CB 1 Rs produces anxiolytic effects in various models of unconditioned fear, relevant to multiple anxiety disorder symptom domains reviewed in [ 30 — 33 ]. Regarding conditioned fear, the effect of CB 1 R activation is complex: CB 1 R activation may enhance or reduce fear expression, depending on brain locus and the eCB ligand [ 34 ]; however, CB 1 R activation potently enhances fear extinction [ 35 ], and can prevent fear reconsolidation.
Genetic manipulations that impede CB 1 R activation are anxiogenic [ 35 ], and individuals with eCB system gene polymorphisms that reduce eCB tone—for example, FAAH gene polymorphisms—exhibit physiological, psychological, and neuroimaging features consistent with impaired fear regulation [ 36 ].
Reduction of AEA—CB 1 R signaling in the amygdala mediates the anxiogenic effects of corticotropin-releasing hormone [ 37 ], and CB 1 R activation is essential to negative feedback of the neuroendocrine stress response, and protects against the adverse effects of chronic stress [ 38 , 39 ].
Accordingly, CB 1 R activation has been suggested as a target for anxiolytic drug development [ 15 , 43 , 44 ]. In addition to dose-dependent activation of TRPV1 channels, the anxiogenic versus anxiolytic balance of CB 1 R agonists also depends on dynamic factors, including environmental stressors [ 33 , 49 ]. In preclinical studies, 5-HT 1A R agonists are anxiolytic in animal models of general anxiety [ 51 ], prevent the adverse effects of stress [ 52 ], and enhance fear extinction [ 53 ].
They are expressed on serotonergic neurons in the raphe, where they exert autoinhibitory function, and various other brain areas involved in fear and anxiety [ 54 , 55 ]. Mechanisms underlying the anxiolytic effects of 5-HT 1A R activation are complex, varying between both brain region, and pre- versus postsynaptic locus, and are not fully established [ 56 ]. Initial studies of CBD in these models showed conflicting results: When tested over a wide range of doses in further studies, the anxiolytic effects of CBD presented a bell-shaped dose—response curve, with anxiolytic effects observed at moderate but not higher doses [ 61 , 90 ].
All further studies of acute systemic CBD without prior stress showed anxiolytic effects or no effect [ 62 , 65 ], the latter study involving intracerebroventricular rather than the intraperitoneal route. No anxiogenic effects of acute systemic CBD dosing in models of general anxiety have yet been reported. As yet, few studies have examined chronic dosing effects of CBD in models of generalized anxiety. Anxiolytic effects in models used: Anxiolytic effects of CBD in models of generalized anxiety have been linked to specific receptor mechanisms and brain regions.
The midbrain dorsal periaqueductal gray DPAG is integral to anxiety, orchestrating autonomic and behavioral responses to threat [ 91 ], and DPAG stimulation in humans produces feelings of intense distress and dread [ 92 ]. The bed nucleus of the stria terminalis BNST serves as a principal output structure of the amygdaloid complex to coordinate sustained fear responses, relevant to anxiety [ 93 ].
In the prelimbic cortex, which drives expression of fear responses via connections with the amygdala [ 94 ], CBD had more complex effects: As noted, CBD has been found to have a bell-shaped response curve, with higher doses being ineffective. Stress is an important contributor to anxiety disorders, and traumatic stress exposure is essential to the development of PTSD.
In a chronic study, systemic CBD prevented increased anxiety produced by chronic unpredictable stress, in addition to increasing hippocampal AEA; these anxiolytic effects depended upon CB 1 R activation and hippocampal neurogenesis, as demonstrated by genetic ablation techniques [ 81 ]. Finally, CBD, partially via CB 1 Rs, decreased defensive immobility and explosive escape caused by bicuculline-induced neuronal activation in the superior colliculus [ 89 ].
Several studies assessed CBD using contextual fear conditioning. Briefly, this paradigm involves pairing a neutral context, the conditioned stimulus CS , with an aversive unconditioned stimulus US , a mild foot shock. After repeated pairings, the subject learns that the CS predicts the US, and subsequent CS presentation elicits freezing and other physiological responses. By contrast, CBD microinjection in the infralimbic cortex enhanced conditioned freezing [ 70 ]. Finally, El Batsh et al.
In this study, CBD was administered prior to conditioning rather than prior to re-exposure as in acute studies, thus further directly comparable studies are required. CBD has also been shown to enhance extinction of contextually conditioned fear responses. Extinction training involves repeated CS exposure in the absence of the US, leading to the formation of a new memory that inhibits fear responses and a decline in freezing over subsequent training sessions.
Further studies showed CB 1 Rs in the infralimbic cortex may be involved in this effect [ 82 ]. CBD also blocked reconsolidation of aversive memories in rat [ 76 ]. Briefly, fear memories, when reactivated by re-exposure retrieval , enter into a labile state in which the memory trace may either be reconsolidated or extinguished [ 97 ], and this process may be pharmacologically modulated to achieve reconsolidation blockade or extinction. Overall, existing preclinical evidence strongly supports the potential of CBD as a treatment for anxiety disorders.
Activation of 5-HT 1A Rs appears to mediate anxiolytic and panicolytic effects, in addition to reducing conditioned fear expression, although CB 1 R activation may play a limited role. While CBD predominantly has acute anxiolytic effects, some species discrepancies are apparent. In addition, effects may be contingent on prior stress and vary according to brain region. Further receptor-specific studies may elucidate the receptor specific basis of this distinct dose response profile.
Further studies are also required to establish the efficacy of CBD when administered in chronic dosing, as relatively few relevant studies exist, with mixed results, including both anxiolytic and anxiogenic outcomes. In particular, results show potential for the treatment of multiple PTSD symptom domains, including reducing arousal and avoidance, preventing the long-term adverse effects of stress, as well as enhancing the extinction and blocking the reconsolidation of persistent fear memories.
The anxiolytic effects of CBD in humans were first demonstrated in the context of reversing the anxiogenic effects of THC.
CBD reduced THC-induced anxiety when administered simultaneously with this agent, but had no effect on baseline anxiety when administered alone [ 99 , ]. Further studies using higher doses supported a lack of anxiolytic effects at baseline [ , ]. By contrast, CBD potently reduces experimentally induced anxiety or fear.
CBD reduced anxiety associated with a simulated public speaking test in healthy subjects, and in subjects with SAD, showing a comparable efficacy to ipsapirone a 5-HT 1A R agonist or diazepam [ 98 , ].
CBD also reduced the presumed anticipatory anxiety associated with undergoing a single-photon emission computed tomography SPECT imaging procedure, in both healthy and SAD subjects [ , ].
Finally, CBD enhanced extinction of fear memories in healthy volunteers: These rCBF changes were not correlated with anxiolytic effects [ ].
In a series of placebo-controlled studies involving 15 healthy volunteers, Fusar-Poli et al. Response activation is diminished in PTSD and other anxiety disorders, and increased activation predicts response to treatment [ ]. CBD produced no changes in predicted areas relative to placebo but reduced activation in the left insula, superior temporal gyrus, and transverse temporal gyrus.
The fearful faces task activates the amygdala, and other medial temporal areas involved in emotion processing, and heightened amygdala response activation has been reported in anxiety disorders, including GAD and PTSD [ , ]. CBD attenuated blood-oxygen-level dependent activation in the left amygdala, and the anterior and posterior cingulate cortex in response to intensely fearful faces, and also reduced amplitude in skin conductance fluctuation, which was highly correlated with amygdala activation [ ].
Dynamic causal modeling analysis in this data set further showed CBD reduced forward functional connectivity between the amygdala and anterior cingulate cortex [ ]. Epidemiological studies of various neuropsychiatric disorders indicate that a higher CBD content in chronically consumed cannabis may protect against adverse effects of THC, including psychotic symptoms, drug cravings, memory loss, and hippocampal gray matter loss [ — ] reviewed in [ ].
As THC acutely induces anxiety, this pattern may also be evident for chronic anxiety symptoms. Two studies were identified, including an uncontrolled retrospective study in civilian patients with PTSD patients [ ], and a case study in a patient with severe sexual abuse-related PTSD [ ], which showed that chronic cannabis use significantly reduces PTSD symptoms; however, these studies did not include data on the THC: Thus, overall, no outcome data are currently available regarding the chronic effects of CBD in the treatment of anxiety symptoms, nor do any data exist regarding the potential protective effects of CBD on anxiety potentially induced by chronic THC use.
Evidence from human studies strongly supports the potential for CBD as a treatment for anxiety disorders: Limited results in healthy subjects also support the efficacy of CBD in acutely enhancing fear extinction, suggesting potential for the treatment of PTSD, or for enhancing cognitive behavioral therapy. Further studies are also required to establish whether chronic, in addition to acute CBD dosing is anxiolytic in human.
Human experimental findings support preclinical findings, and also suggest a lack of anxiogenic effects, minimal sedative effects, and an excellent safety profile. Overall, this review emphasizes the potential value and need for further study of CBD in the treatment of anxiety disorders.
Disclosure forms provided by the authors are available with the online version of this article. National Center for Biotechnology Information , U. Journal List Neurotherapeutics v. Published online Sep 4. Blessing , 1 Maria M. Steenkamp , 1 Jorge Manzanares , 1, 2 and Charles R. Author information Copyright and License information Disclaimer. This article has been cited by other articles in PMC. Abstract Cannabidiol CBD , a Cannabis sativa constituent, is a pharmacologically broad-spectrum drug that in recent years has drawn increasing interest as a treatment for a range of neuropsychiatric disorders.
Electronic supplementary material The online version of this article doi: Cannabidiol, Endocannabinoids, Anxiety, Generalized anxiety disorder, Post-traumatic stress disorder. Introduction Fear and anxiety are adaptive responses essential to coping with threats to survival. CBD Pharmacology Relevant to Anxiety General Pharmacology and Therapeutic Profile Cannabis sativa , a species of the Cannabis genus of flowering plants, is one of the most frequently used illicit recreational substances in Western culture.
Table 1 Preclinical studies. Open in a separate window. Effective doses are in bold Receptor specific agents: Stress-induced Anxiety Models Stress is an important contributor to anxiety disorders, and traumatic stress exposure is essential to the development of PTSD. Summary and Clinical Relevance Overall, existing preclinical evidence strongly supports the potential of CBD as a treatment for anxiety disorders. Table 2 Human psychological studies. Table 3 Neuroimaging studies.
Evidence from Epidemiological and Chronic Studies Epidemiological studies of various neuropsychiatric disorders indicate that a higher CBD content in chronically consumed cannabis may protect against adverse effects of THC, including psychotic symptoms, drug cravings, memory loss, and hippocampal gray matter loss [ — ] reviewed in [ ]. Summary and Clinical Relevance Evidence from human studies strongly supports the potential for CBD as a treatment for anxiety disorders: Electronic supplementary material Below is the link to the electronic supplementary material.
Required Author Forms Disclosure forms provided by the authors are available with the online version of this article. Anxiety disorders in primary care: Suicide risk in patients with anxiety disorders: Quality of life in the anxiety disorders: Twelve-month use of mental health services in the United States: Cost of disorders of the brain in Europe An effect-size analysis of the relative efficacy and tolerability of serotonin selective reuptake inhibitors for panic disorder.
Remission rates in patients with anxiety disorders treated with paroxetine. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.
Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug. Antidepressant-like and anxiolytic-like effects of cannabidiol: A chemical compound of Cannabis sativa. Endocannabinoid system and mood disorders: Endocannabinoid system and psychiatry: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Safety and side effects of cannabidiol, a Cannabis sativa constituent.
Are cannabidiol and Delta 9 -tetrahydrocannabivarin negative modulators of the endocannabinoid system? Some like it hot. Endocannabinoid signaling in the brain. Lee SH, et al. Multiple forms of endocannabinoid and endovanilloid signaling regulate the tonic control of GABA release. TRPV channels in the brain. Modulation of defensive behavior by transient receptor potential vanilloid type-1 TRPV1 channels.
The Best Cannabis Strains for Anxiety
It does not seem to have adverse side effects, but CBD oil is illegal in some states . forms of anxiety, including social anxiety disorder, panic disorder, obsessive- compulsive disorder, generalized anxiety disorder, and post-traumatic stress disorder. Does CBD oil work for chronic pain management?. Cannabis oil is said to work with a brain receptor known as CB1. CBD for treating anxiety in response to other forms of anxiety such as post-traumatic stress disorder (PTSD), social anxiety disorder (SAD), and anxiety-induced insomnia. CBD Oil for Depression – Will Cannabis Oil Help My Depression?. There exist clinical anxiety issues like social anxiety, PTSD, and OCD, and Cannabis oil can be added to nourishment or basically dropped straight under which oils for anxiety and depression can be utilized as a viable treatment. They took ten individuals with social anxiety who had never had any.