California also has a list of conditions that medical cannabis may be used for, including “any In some cases, he advises patients to begin cannabis as they wean off their opioid pain relief and reduced inflammation, as they metabolize the compound. Addiction Medicine · Bracing/Splinting/Prosthesis · Complementary. CBD oil is one of at least 85 cannabinoid compounds found in cannabis and is popular for Various cannabis plants can have different amounts of CBD and THC suggested to be antagonistic to the psychoactive properties of THC in many . compound to use for transitioning an individual off addictive use of marijuana. Can marijuana's use for pain relief slow the opioid epidemic? in Cannabis plants or certain synthetic compounds — can be effective relief and could even help to reduce the number of people addicted to "Once they have effectively weaned themselves off their opiates onto cannabis, . Most Popular.
compound meds popular people some The pain wean may help off cannabis addictive
THC needs to be decarboxylated usually by applying heat over F before it becomes psychoactive. A new powerful report published by the American National Academies of Sciences has examined the amount of research that has been published for years on the use of cannabis for medical or recreational purposes, establishing for the first time with a certain claritywhat are the positive and negative effects on proven health.
In order not to be deformed ,be informed. Overcome your lost of appetite, cure insomnia,. For your health prescriptions and medical purchases contact An. Do contact for supplies of. Feel free to contact us whenever you have a. I am 17 and have been using medical for about 2 years not smoking, just oil and making smoothies with the sun leaves and refuse to take prescription medication from the hospital, it has helped a LOT with my anxiety and depression, i cant even explain how much.
Two years ago my grandmother was diagnosed with a glioblastoma the size of a baseball, she started using the oil and started juicing to help shrink the tumor. Although this year as soon as she stopped, the cancer came right back and she is in the hospital again now. I am really confused about this study. I read lots of article which it says Marijuana have bad effect on brain in long term and some article says opposite.
Could you introduce a reliable website I can read about Marijuana more? My husband has been taking Xarelto AND Pletal as prescribed by a doctor despite pharmacists filling the prescriptions with a bit of shock and stating they should not be taken together since he had a DVT in his thigh. This happened after knee surgery in Jan , flying 13 hours in March totally unaware or warned by our doc that this was dangerous after surgery. He was inches from death for approx 6 days and then 10 days induced coma total in ICU, 1 month in hospital recovering thankfully learning to walk again etc.
Since then he has been on 10mg Xarelto night dose and mg Pletal morning dose and we have been too terrified to reduce the dose in any way even though the docs in Philippines said continue life long Xeralto and then wean off Pletal after 3 months, because the doc in Spain when we came back here said, leave it as it is. Since then my husband and I have both lost weight.
Ive lost over 40lbs and still losing as I was obese and am still overweight but its just naturally slowly coming off. They will not respond! While its legal here to use medical cannabis, the lack of knowledge by doctors here including a Dutch doctor, make it difficult to consult on the interaction and the possibility of what we desire, which is to cut down on his Xarelto and Pletal, even if its just incremental, i.
This is our hope, but we are on our own as far as knowledge of the two sides i. It will be we who decide IF to wean, which drug to wean off, or a bit of both, or all of one..
So finally to my question Whats the question? If his blood work comes back that all is ok re blood texture clotting etc, then weaning off is bad? Why the muscle loss? He has also experienced some dizziness light headed this last year which again, timing wise, ties into the addition of FECO to his diet but Im not blaming the FECO, Im hoping the FECO is acting as a blood thinner and that we can reduce the Chem meds which according to studies Ive read with tears streaming down my face, have multiple side effects.
Since the incident in Ive suffered from PTSD and my sincerest wish is to if not have closure on this, to after 5 years, adjust his medication and see some sort of forward progress in that area.
The idea of him taking this the rest of his life when it may be unnecessary is horrific. We do not have access to a medical doctor who is also familiar with cannabis, so Peter I ask of you with your background and your education and family history with your grandfather, do you feel we are on the right track?
My husband seems healthy but his muscle loss over the last 7 months is dramatically visible and it frightens me him too quietly but he doesnt say much and he is tired a lot but at the same time very active. This is an ex rugby player, full of energy who moves and is busy all day. He should not be losing muscle mass. No one can answer our questions or even nudge us in the right direction. A nudge from you would be very much appreciated.
When have we crossed a line? He needs that muscle mass to take him through the rest of his life, his muscle mass at the time of the incident in is what saved his life without doubt.. Should the same thing happen today I know I would lose him. Any thought please xx. Hi Neva, Thank you for your comment. You situation is really complicated! I would definitely consult with a Hematologist, ideally one who is comfortable with cannabis therapeutics, so they can see this issue from all sides.
This might be hard to find but hopefully you can connect with one. What about Cardiovascular effects of Marijuana? There so many different opinions and contradictions in research online i dont even know what to listen to. And because its so politically polarized with politicians and special interest Big Pharma? For example, some studies may imply cannabis causes some or other ill consequence but, if you actually read the study carefully, the cannabis and the ill consequence are just randomly associated, and have no causal relationship to each other whatsoever, and may even be caused by the same root causes.
Thanks for your reply. I agree and there needs to be a lot more non byas research especially for medical marijuana patients that are concerned about there heart and health. It would be nice to know the real effects and what we are dealing with.
Thank you very much for sharing this great article about Medical Cannabis. You are most welcome to take a look at this article, about the same topic: Thank you for this blog. It is interesting as well as informative. Does one go to the pharmacy to pick up your med? Once certified by a physician, patients typically go to a dispensary to pick up their medical cannabis. As a Canadian I am pleased to report the legality of using cannabis is confidently striding into the near future.
There is some interesting evidence along these lines, for example: I really appreciate this piece. As a SICI fellow my focus is on solving the problem of misinformation and missing information and chaos of regulating a highly politicized controlled substance. There are huge gaps in our knowledge and credible analysis of the information that is available.
Do you have any suggestions of who I should reach out to? My email is kht student. I can help but not via mechanism of response to comments on blog; please reach out to me via my website petergrinspoon.
Hello Peter, I am currently writing a research paper on the benefits of medical marijuana and was wondering if you could provide me with a few reliable sources, or maybe a list of benefits? Hi Roberto, this is a good resource: Is it true that marijuana can actually help to loss weight? I have been reading this marijuana strain here in and all it says that it can help you relax and chill you physically and mentally. Some of them might even help you with depression and anxiety but this issue regarding losing weight when using marijuana is just fascinating.
Can you enlighten me with some new information about this? There is some research along those lines. This article sums it up. Hi Daniele, Just to offer my experience. I started taking Full Extract Cannabis Oil 9 months ago this has THC but the psychoactive effects can be avoided by weaning on very slowly, very very very slowly with tiny tiny micro doses I hate the psychoactive effects. I am 58 and have been obese for about 10 years. Slowly gently but relentlessly downwards.
I still today cant believe it because i had genuinely given up, 58 years old and very fat with sore knees and nothing I did diligently might I add changed a thing, in fact everything I tried resulted in an increased weight after the fact. Cannabis has made me lose a huge amount of weight and I am still consistently gently heading downwards. Please note, I researched strains and studied for months and months before taking the oil, I grew my own plants and made my own Full Extract Oil with a clean solvent ethanol using the Rick Simpson method which is safest for home makers, except for his solvents which are not clean, so I used his method with rice cooker but I used my own choice of a clean solvent which is ethanol food grade.
If you are contemplating taking this oil you need to self educate, you need to understand that the oil has THC in it and you need to wean on super slowly to use it without the horrible psychoactive feelings that the THC bring if you have not weaned on slowly, and you need to be patient once you start.
Might I suggest that you start with a tincture as I did until I was no longer scared of it, tincture is not as strong and is a good prelude to starting on the oil. And high numbers of opioid receptors in the gut — thanks in part to all the nerve endings there — can trigger constipation and sometimes nausea. No matter how much I say I want to avoid opioids, half of my patients will get some kind of opioid. Plus, opioids are highly addictive. Gradually, the opioid receptors in the brain become less sensitive to the drugs, so the body demands higher and higher doses to get the same feel-good benefit.
If a person tries to go without the drugs, withdrawal symptoms like intense sweating and muscle cramps kick in — the body is physically dependent on the drugs. Addiction is a more complex phenomenon than dependence, involving physical cravings so strong that a person will go to extreme lengths to get the next dose. Long-term users of prescription opioids might be dependent on the drugs, but not necessarily addicted.
But dependence and addiction often go together. Despite their risks, opioids are still widely used because they work so well, particularly for moderate to severe short-term pain. In the late s and early s, more doctors began doling out the drugs for long-term pain, too. Aggressive marketing campaigns from Purdue Pharma, the maker of OxyContin, promised that the drug was safe — and doctors listened.
Opioid overdoses nearly quadrupled between and , with almost half of those deaths coming from opioids prescribed by a doctor, according to data from the U. Centers for Disease Control and Prevention. Opioid prescriptions rose in the United States throughout the s and early s. Physicians have begun to back off in the last few years. Opioid prescriptions have dipped a bit since , thanks in part to stricter prescription laws and prescription registration databases.
Some people have turned to more dangerous street alternatives like heroin. And those drugs are sometimes spiked with more potent opioids such as fentanyl SN: Overdose deaths from fentanyl and heroin have both spiked since , CDC data reveal. Scientists have been searching for a drug that kills pain as successfully as opioids without the side effects for close to a hundred years, with no luck, says Sam Ananthan, a medicinal chemist at Southern Research in Birmingham, Ala.
He is newly optimistic. Scientists used to think opioid receptors were simple switches: If a molecule latched on, the receptor fired off a specific message. But more recent studies suggest that the same receptor can send multiple missives to different recipients. And in a follow-up study, negative effects were less likely. Bohn and colleagues figured out that mu opioid receptors — the type of opioid receptor targeted by most drugs — send two different streams of messages.
The other, which needs beta-arrestin 2, drives many of the negatives of opioids, including the need for more and more drug and the dangerous slowdown of breathing. Scientists have identified dozens of molecules that seem to avoid beta-arrestin 2 in mice. But only a few might make good drugs. One, called PZM21 , was described in Nature last year. Morphine, a powerful opioid, is extracted from poppy plants.
When it connects with the opioid receptor blue , it relieves pain, but also causes negative effects. Scientists have figured out which molecular messages trigger pain relief and which activate problems. The aim is to design new molecules, such as PZM21, that interact with the opioid receptor to instigate only pain relief. Another one has shown promise in humans — a much higher bar.
The pharmaceutical company Trevena, headquartered in King of Prussia, Pa. In studies reported in April in San Francisco at the Annual Regional Anesthesiology and Acute Pain Medicine Meeting, oliceridine was as effective as morphine in patients recovering from bunion removal and others who had tummy tuck surgeries.
Over the short term, people taking a moderate dose of the drug got pain relief comparable to that of morphine, but reported fewer side effects, such as vomiting and breathing problems. Oliceridine is an intravenous opioid, not an oral one.
That means it would be administered in the short term in hospitals, during and after surgeries. More side effects cropped up at higher doses. The company hopes to submit an application for FDA approval by the end of , Violin says. His team showed that mice lacking a different opioid receptor, the delta receptor, tended not to show negative effects in response to the drugs. Now, the researchers are trying to find molecules that can activate mu opioid receptors while blocking delta receptors.
In one recent study, scientists described a molecule that bound to opioid receptors only when the area around the receptors was more acidic than normal. And they were less likely to have constipation and slowed breathing. Drugs face a long uphill climb from even the most promising animal studies to FDA approval for use in humans. Very few make it that far. And scientists are trying to catch up. In August , the Drug Enforcement Administration announced that it was cracking down on a supplement called kratom.
Officials wanted to put the herb in the same regulatory category as heroin and LSD, labeling it a dangerous substance with no medical value. Members of the public vehemently disagreed. More than 23, comments poured in from veterans, cancer survivors, factory workers, lawyers and teachers.
Almost all of them said the same thing: Kratom freed them from pain. Some chronic opioid users switch to kratom to wean themselves off of pain pills and ease withdrawal symptoms, says Oliver Grundmann, a medicinal chemist at the University of Florida in Gainesville.
Schrank, who readily concedes there are possible health and addiction risks with marijuana, says he offers his cannabis detox and maintenance protocol to people addicted to crack cocaine as well as those trying to kick opioids.
Through the years, he says, he's treated about 50 people with this technique and expects to see "more people wanting to try to have a voice in their recovery rather than just plug into systems telling them what to do.
Marijuana "can really help people with pain management and other health issues, or it can help them be safer," Schrank said. Yasmin Hurd, director of the Addiction Institute at Mount Sinai School of Medicine , says generally, cannabidiol is the more important compound when it comes to marijuana as a treatment for addiction. In terms of the wider scope of medical marijuana research, this is the "same cannabidiol being looked at for the kids with epilepsy," Hurd said.
THC, she says, binds to cannabinoid receptors in our brains as do the natural cannabinoids our bodies produce , and it is the stimulation of those receptors that brings a "high. Yet cannabidiol reverses some of the brain changes that occur with heroin use, Hurd says, based on her own studies of the compound. Prescriptions may hold clues to who gets hooked on opioids, study says. For instance, heroin harms the glutamate transmitter system, which is important for decision-making, cognition and even reward, explains Hurd.
Similarly, cannabidiol reversed damage to the cannabinoid receptors themselves caused by heroin, while activating the serotonin system: More generally, cannabidiol positively influences our biological systems that are linked to the negative components of addiction, such as anxiety and inhibitory control, Hurd suggests.
She notes that although cannabidiol is believed to be a "treatment to consider for opioid addiction and other drugs," there aren't a lot of data, especially with regard to its potential effects for cocaine addiction. Adding to the data is a recent study, funded in part by a company applying to the Canadian government for a license to produce medical cannabis, exploring one possible harm reduction plan: Crack cocaine is said to be a low-end incarnation of a rich man's drug.
Cocaine, an expensive stimulant made from the leaves of the coca plant native to South America, can be processed to make a cheap crystal rock or "crack. This form becomes much higher-risk to users who are likely to share needles. Your brain on weed Milloy and his colleagues measured and analyzed how frequently drug users smoked or injected crack before, during and after a period of cannabis use, based on their own self-reports.
Crack use did not decrease during the period when participants intentionally self-medicated with cannabis, compared with the time before trying marijuana. Afterward, crack use decreased significantly, with participants reporting using it on average about half as often as before the intervention. Indeed, I think what it really is, it may be a first step," Milloy said of his study, which was recently published in the journal Addictive Behaviors.
To that end, we are putting together a clinical trial, which we hope will better test the hypothesis that cannabis could be useful to people who are suffering from this disorder. Which doctor you see could determine how long you use opioids, study says. Although the Vancouver study did not investigate the brain science to explain how marijuana might have this effect, Milloy and his co-authors say that emerging data "provide biological plausibility" for the findings.
New potential for marijuana: Treating drug addiction
Describing his experience in treating pain with medical cannabis over the said he starts with some basic criteria, including that patients have not responded to efforts for pain relief with standard therapy. . in completely weaning patient off of opioids and switching to cannabis in . Most Popular Articles. Could the cannabis-based medicine CBD oil be the cure for pain? For many people experiencing chronic pain, cannabidiol (CBD) oil has steadily A compound found in the marijuana plant, cannabidiol is sometimes touted as an One person was able to completely wean off oral opioid analgesic pain medication. You can take painkillers safely to relieve your pain. But for a variety of reasons, painkillers can be dangerous, too. As you're probably aware, some people become dependent on painkillers or addicted to painkillers. . speak to your doctor and ask about the best way to wean yourself off the drug.