1: Nauta HJ, McIlwrath SL, Westlund KN. Punctate Midline Myelotomy Reduces Pain Responses in a Rat Model of Lumbar Spine Pain: Evidence that the. Full-text available. Mar ; European journal of pain (London, England). [ object Object]. S.L. McIlwrath · [object Object]. R. Nesemeier · [object Object]. F. Ma; [. Neurotree: publications by Sabrina McIlwrath, University of Pittsburgh.
Initial studies have quantitatively compared the properties of normal and post-injury cutaneous nociceptive sensory neurons. Results of these studies demonstrate that specific types of nociceptive sensory neurons demonstrate differing degrees of sensitization commensurate with the type of injury.
The aims of future studies are to determine how changes in the expression of these growth factors in the skin following injury can lead to changes in afferent fiber sensitivity.
Possible mechanisms for this sensitization include modulating the expression of mechanically and thermally sensitive ion channels e. In addition to genetically altered mice, more recent projects employ a novel in vivo siRNA strategy that allows for the investigation of the potential roles of specific channels and receptors at the molecular level. Koerber's laboratory have the opportunity to learn a variety of neurophysiological, neuroanatomical, behavioral, and molecular biological techniques.
These techniques allow for a robust examination of the response characteristics of the adult and developing nervous system to injury. Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo. Low dose, peripherally restricted opiate loperamide attenuated both mechanical and heat hypersensitivity.
Mice fed an alcohol and high fat diet develop histology consistent with chronic pancreatitis as well as opioid sensitive mechanical and heat hypersensitivity. This is exactly what Open Access Journals provide and this is the reason why I support this endeavor.
Open Access publishing is therefore of utmost importance for wider dissemination of information, and will help serving the best interest of the scientific community.
They offer accessible information to a wide variety of individuals, including physicians, medical students, clinical investigators, and the general public. They are an outstanding source of medical and scientific information. Indeed, the research articles span a wide range of area and of high quality.
This is specially a must for researchers belonging to institutions with limited library facility and funding to subscribe scientific journals. They provide easy access to the latest research on a wide variety of issues. Relevant and timely articles are made available in a fraction of the time taken by more conventional publishers. Articles are of uniformly high quality and written by the world's leading authorities. Open access journals are very helpful for students, researchers and the general public including people from institutions which do not have library or cannot afford to subscribe scientific journals.
The articles are high standard and cover a wide area. In this perspective, open access journals are instrumental in fostering researches and achievements. World Journal of Gastroenterology: The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors. Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers. Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors.
The Journal of Neuroscience: Deletion of P2X3 receptors blunts gastro-oesophageal sensation in mice. Sensitization of cutaneous nociceptors after nerve transection and regeneration: Sox11 transcription factor modulates peripheral nerve regeneration in adult mice.
The Open Pain Journal
The Mas-related G protein-coupled receptor D (Mrgprd) is selectively expressed in nonpeptidergic nociceptors that innervate the outer layers of mammalian skin. Previous studies in our laboratories found that isolectin B(4)(IB(4))-positive polymodal nociceptors in the mouse do not express transient receptor potential. , – () M.P. Price, G.R. Lewin, S.L. McIlwrath, C. Cheng, J. Xie, P.A. Heppenstall, C.L. Stucky, A.G. Mannsfeldt, T.J. Brennan, H.A. Drummond.